Description
Equipment Technical Description
The Zetasizer Advance Pro is a state-of-the-art analytical system designed for the physicochemical characterization of nanoparticles, colloids, and macromolecules in suspension. It integrates Dynamic Light Scattering (DLS) and Electrophoretic Light Scattering (ELS) techniques to determine hydrodynamic diameter and zeta potential, respectively. Equipped with the patented NIBS (Non-Invasive Back Scatter) optical technology, featuring detection angles of 173° and 13°, the instrument enables the analysis of samples over a size range from 0.3 nm to 10 mm and concentrations up to 40% w/v, minimizing multiple scattering artefacts.
Equipment Application Description
The system is widely used for the characterization and optimization of nanotechnological, biological, and colloidal systems, providing real-time assessment of colloidal stability, particle size, and aggregation potential. By monitoring hydrodynamic diameter and zeta potential, the instrument supports the development of drug delivery systems (such as liposomes, polymeric nanoparticles, and lipid-based carriers), the stability monitoring and aggregate detection of proteins and monoclonal antibodies, and the optimization of emulsions and suspensions in the cosmetic, food, and chemical industries.
Main Technical Specifications
- Integrated Techniques: DLS (Particle Size) and ELS (Zeta Potential)
- Measurement Range (Particle Size): 0.3 nm to 10 mm (Hydrodynamic Diameter)
- Measurement Range (Zeta Potential): Suitable for particles from 3.8 nm to 100 mm
- DLS Detection Angles: 173° (NIBS Backscatter) and 13° (Forward Scatter)
- Minimum Sample Volume: 12 µL (using capillary cells)
- Temperature Range: 0 °C to 120 °C
- Software Interface: ZS Xplorer (including AI-assisted diagnostics)
